Thalidomide holds a special place in drug discovery lore. Initially marketed in Europe in the 1950s to help pregnant women overcome morning sickness and to help them sleep, thalidomide was found to be ...

We’ve repeatedly asked for State apology and fear some of our survivors and families won’t be around to hear it’ ...

Melbourne thalidomider Lyn Rowe (right) won her legal case for compensation in 2012, at age 50. Supplied by the Rowe Family/AAP Welcome to part two of the Conversation’s thalidomide series. In this ...

Scientists have studied thalidomide's target protein, cereblon (CRBN), and its binding protein, AMP-activated protein kinase (AMPK), which plays an important role in maintaining intracellular energy ...

Thalidomide, a morning-sickness drug recalled in the 1960s because it caused devastating birth defects, is now commonly used to treat multiple myeloma and other blood cancers. It and its chemical ...

The drug was originally used to treat morning sickness in the late 50s. Stephencdickson/ Wikimedia Commons, CC BY-SA In the midst of the coronavirus pandemic, researchers have turned to existing ...

A study points to the possibility that thalidomide derivatives are potentially suitable for treating cancer. Thalidomide was marketed in the 1950s as a sleeping pill. It later gained sad notoriety for ...

PURPOSE: Little progress has been made in the treatment of adult high-grade gliomas over the last two decades, thus necessitating a search for novel therapeutic strategies. Malignant gliomas are ...

Thalidomide demonstrated superior efficacy in preventing the relapse of immunoglobulin G4–related disease (IgG4-RD) during a 12-month follow-up period in a placebo-controlled trial. The treatment ...

The antiangiogenic properties of thalidomide that caused birth defects when the drug was given to pregnant women have led to an interest in its potential therapeutic applications. Researchers at the ...

THALIDOMIDE IS a drug with a long and checkered history. Originally developed and marketed as a sedative in pregnancy, thalidomide produced disastrous teratogenic effects when taken by women in the ...

The same property of thalidomide that caused birth defects when it was given to pregnant women—the inhibition of blood vessel formation (anti-angiogenesis)—has led to an interest in thalidomide's ...